Graduate Academic Programs

Exposure to Metalworking Fluids and Cancer Incidence in the United Auto Workers-General Motors Cohort

Hilary Colbeth
Kevin Chen
Sally Picciotto
Sadie Costello, PhD, MPH
Ellen A Eisen
2023

In previous studies, investigators have reported increased risks of specific cancers associated with exposure to metalworking fluids (MWFs). In this report we broadly examine the incidence of 14 types of cancer, with a focus on digestive, respiratory, and hormonal cancers, in the United Auto Workers-General Motors (UAW-GM) cohort, a cohort of workers exposed to MWFs (1973-2015). The cohort included 39,132 workers followed for cancer incidence. Cox models yielded estimates of adjusted hazard ratios, with categorical variables for lagged cumulative exposure to 3 types of MWF (straight...

Distribution of working hour characteristics by race, age, gender, and shift schedule among U.S. manufacturing workers

Jacqueline M Ferguson
Patrick T Bradshaw
Ellen A Eisen
David Rehkopf
Mark R Cullen
Sadie Costello
2023

Shift work is a common occupational exposure, however, few studies have examined aspects of shift work beyond night work and long hours, such as rotational patterns or weekend work, which may contribute to poor health through disruption of the body's circadian rhythms. In this manuscript, we calculated the prevalence of working hour characteristics using algorithms for type (e.g., day), duration, intensity, rotational direction, and social aspects (e.g., weekend work) in a nationwide cohort of American manufacturing workers (N = 23,044) between 2003 and 2014. Distributions of working...

Suicide prevention-related Google searches and subsequent emergency department visits in California and Arizona, 2007-2015

Hilary Colbeth
Sidra Goldman-Mellor
Ellen A Eisen
Krista Neumann
Ralph Catalano
Corinne A Riddell
2024

Introduction: United States emergency departments (ED) visit rates for nonfatal self-harm increased by 42% from 2001 to 2016. Previous suicide mortality research has provided conflicting evidence on the use of suicide-related Internet searches as a surveillance tool for self-harm and suicidal ideation. However, few have used rigorous approaches to account for autocorrelation at the aggregate level, and none have focused on Internet searches related to suicide prevention.

Methods and results: Over a 9-year study period (2007-2015), suicidality-...

Measuring long-term exposure to wildfire PM2.5 in California: Time-varying inequities in environmental burden

Joan A Casey
Marianthi-Anna Kioumourtzoglou
Amy Padula
David J X González
Holly Elser
Rosana Aguilera
Alexander J Northrop
Sara Y Tartof
Elizabeth Rose Mayeda
Danielle Braun
Francesca Dominici
Ellen A Eisen
Rachel Morello-Frosch
Tarik Benmarhnia
2024

Wildfires have become more frequent and intense due to climate change and outdoor wildfire fine particulate matter (PM2.5) concentrations differ from relatively smoothly varying total PM2.5. Thus, we introduced a conceptual model for computing long-term wildfire PM2.5 and assessed disproportionate exposures among marginalized communities. We used monitoring data and statistical techniques to characterize annual wildfire PM2.5 exposure based on intermittent and extreme daily...

Worker exit and suicide and overdose mortality in a cohort of male non-metal mine workers

Hilary Colbeth
Jacqueline M Ferguson
Sally Picciotto
Stella Koutros
Debra T Silverman
Ellen A. Eisen
2025
Background:

Suicides, overdoses, and drug-related liver diseases (deaths of despair) are greatly elevated in the mining and extraction industries compared to other industries. To better understand the drivers of these deaths, we examined suicide or overdose mortality in relation to age at worker exit among a retrospective cohort of 11,009 male mine workers from the Diesel Exhaust in Miners Study II.

Methods:

We calculated age-adjusted mortality rates (1947–2015) and estimated hazard ratios (HRs) and 95% Confidence Intervals (CI) for suicide or overdose death in relation to...

Contribution of Involuntary Job Loss to the Burden of Depressive Symptoms Over Two Decades in a National Study of Aging Adults

Sally Picciotto
Ellen A. Eisen
David H Rehkopf
Amy L Byers
2024

Objectives: In recent decades, risk of job loss in America after age 50 has been high, potentially causing significant stress during the period preceding retirement. Yet no study has quantified the burden of clinically relevant depressive symptoms attributable to job loss in this age group over this period or identified the most vulnerable populations.

Methods: Participants aged 50+ in the Health and Retirement Study (recruited 1992-2016) who were employed and scored <5 on the Center for Epidemiologic Studies-Depression 8-item scale (CESD-8) at...

The Impact of Increasing Workforce Racial Diversity on Black-White Disparities in Cardiovascular Disease Mortality

Hilary Colbeth
Corinne A. Riddell
Marilyn D. Thomas
Mahasin S. Mujahid
Ellen A. Eisen
2024

Background.—Structural racism’s influence on workforce policies and practices presents possible upstream targets for assessing and reducing racial health disparities. This study is the first to examine workforce racial diversity in association with racial disparities in cardiovascular disease (CVD) outcomes.

Methods.—This retrospective cohort study of 39,693 hourly autoworkers from three Michigan automobile plants, includes 75 years of follow-up (1941–2015). Workforce racial diversity (percent Black autoworkers) was a plant and year level variable. Annual exposure was cumulated over...

Estimating the Exposure-Response Relationship between Fine Mineral Dust Concentration and Coccidioidomycosis Incidence Using Speciated Particulate Matter Data: A Longitudinal Surveillance Study

Amanda K Weaver
Nicole Keeney
Jennifer Head
Alexandra K Heaney
Simon Campo
Philip Collender
Abinash Bhattachan
Gregory S Okin
Ellen A. Eisen
Gail Sondermeyer-Cooksey
Alexander Yu
Duc J Vugia
Seema Jain
John Balmes
John Taylor
Justin V Remais
Matthew J Strickland
2025

Background: Coccidioidomycosis, caused by inhalation of Coccidioides spp. spores, is an emerging infectious disease that is increasing in incidence throughout the southwestern US. The pathogen is soil-dwelling, and spore dispersal and human exposure are thought to co-occur with airborne mineral dust exposures, yet fundamental exposure-response relationships have not been conclusively estimated.

Objectives: We estimated associations between fine mineral dust concentration and coccidioidomycosis incidence in California from 2000 to 2017 at the census...

Evaluating Natural Course Performance in Parametric G-formula: Review of Current Practice and Illustration Based on the United Autoworkers-General Motors Cohort

Wenxin Lu
Sally Picciotto
Sadie Costello
Hilary Colbeth
Ellen Eisen, PhD, ScD
2024

The parametric g-formula is a causal inference method that appropriately adjusts for time-varying confounding affected by prior exposure. Like all parametric methods, it assumes correct model specification, usually assessed by comparing the observed outcome with the simulated outcome under no intervention (natural course). However, it is unclear how to evaluate natural course performance and whether other variables should also be considered. We reviewed current practices for evaluating model misspecification in applications of parametric g-formula. To illustrate the pitfalls of...

Mixture analysis identifies ozone as driving factor for child asthma symptoms

Wenxin Lu
Ellen A. Eisen
Liza Lutzker, MPH
S Katharine Hammond
Stephanie Holm, MD, MPH
John R. Balmes
2025

Background

The natural distributions of ambient air pollutants are often correlated. Existing studies have found that exposures to various air pollutants are associated with elevated risks of asthma symptoms among children. However, most studies applied single-pollutant models, which cannot distinguish between causal effects and associations due to correlations with other measured or unmeasured pollutants. Objective Investigate air pollutant mixtures and child asthma symptoms and identify key risk factors. Methods The Children’s Health and Air Pollution Study (CHAPS) recruited 299...